Two hundred patients who’ve failed to get better using existing treatments will take part – some getting a placebo, the rest twice-weekly ketamine treatments.
Previous trials have shown ketamine “produces rapid antidepressant effects within hours”, says research leader UNSW Professor Colleen Loo, but the long-term effects aren’t yet known.
“This trial will allow us to examine the effects of repeated dosing and whether the positive effects of ketamine on an individual’s depression can be sustained over a longer period.”
The patients won’t know if they’re getting a placebo or ketamine, nor will the doctors administering the treatment.
After the trial ends, patients who are responding well will be given the chance to keep taking ketamine.
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