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Experimental Medication Lifts Depression Symptoms in Bipolar Disorder Within an Hour

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People with treatment-resistant bipolar disorder experienced relief from symptoms of depression in as little as 40 minutes after an intravenous dose of the anesthetic medication ketamine in a preliminary study; while the patient group was small, this work adds to evidence that compounds in the class to which ketamine belongs have potential as rapid and … Read more

Ketamine Lifts Depression via a Byproduct of its Metabolism

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NIH-funded team finds rapid-acting, non-addicting agent in mouse study. A chemical byproduct, or metabolite, created as the body breaks down ketamine likely holds the secret to its rapid antidepressant action, National Institutes of Health (NIH) scientists and grantees have discovered. This metabolite singularly reversed depression-like behaviors in mice without triggering any of the anesthetic, dissociative, … Read more